How to Treat Chronic Kidney Disease with Food

“In the United States, approximately one in three adults aged 65 years and older has chronic kidney disease (CKD),” as I note in my video Treating Chronic Kidney Disease with Food, but the “majority of patients with CKD do not progress to advanced stages of CKD because death precedes the progression to end-stage renal disease…” Following about a thousand folks 65 years or older with chronic kidney disease for about a decade, only a few had to go on dialysis because most died. The scariest thing for many kidney patients is the fear of dialysis, but they may be 13 times more likely to die than go on dialysis. With heart disease killing more than nearly all other causes combined, decreasing kidney function can set one up for heart attacks, strokes, and death.

That’s why it’s critical that any diet chosen to help the kidneys must also help the heart. A plant-based diet fits the bill, providing protection against kidney stones, kidney inflammation, and acidosis, as well as heart disease. (See below for links to my videos covering these very topics.) That is, “blood pressure control may be favored by the reduction of sodium intake and by the vegetarian nature of the diet, which is very important also for lowering serum cholesterol,” which may not only help the heart but also the kidneys themselves.

In 1858, Rudolf Virchow, the father of modern pathology, was the first to describe the fatty degeneration of the kidney. In 1982, this idea of lipid nephrotoxicity—the possibility that fat and cholesterol in the bloodstream could be toxic to the kidneys directly, based on data showing plugs of fat literally clogging up the works in autopsied kidneys—was formalized.

Since the notion was put forth, it has gained momentum. It appears high cholesterol and fat in the bloodstream may accelerate the progression of chronic kidney disease through direct toxic effects on the kidney cells themselves. Given the connection between cholesterol and kidney decline, the use of cholesterol-lowering statin drugs has been recommended to slow the progression of kidney disease. Of course, “[s]erious adverse effects on muscle and liver must be kept in mind.” This is why plant-based diets could offer the best of both worlds, protecting the heart and the kidneys without drug side effects.

The two potential drawbacks are the amount of phosphorus and potassium in plant foods, which ailing kidneys can sometimes have a problem getting rid of. It turns out, however, that the phosphorus in meat is absorbed at about twice the rate, not to mention the phosphate additives that are injected into meat. So, eating plant-based can significantly lower phosphorus levels in the blood. The concern about potassium is largely theoretical because the alkalinizing effects of plant foods help the body excrete potassium, but it is not theoretical for those on dialysis or with end-stage disease who need to be closely followed by a dietician kidney specialist.

Special protein-restricted vegan diets have been used successfully to slow or stop the progression of kidney failure. One study showed the declining kidney function of eight diabetics for one to two years before switching to the plant-based diet, which appeared to stop the inexorable decline in most of the patients. This led the researchers to proclaim it as the treatment of choice for diabetic kidney failure.

Strictly plant-based diets may also help delay dialysis by one to two years and, after kidney transplant, may improve the survival of the kidney and improve the survival of the patient. Most of the papers, though, are just pilot feasibility studies. It doesn’t matter if it’s effective if we can’t get people to stick to the diet. But while we’re waiting for more definitive studies, existing data support offering these kinds of plant-based diets as an option to all patients with advanced or progressive chronic kidney disease.

“[E]ven if the effects of such diets on the progression of renal failure are still debatable, the unquestionably favorable effects [of plant-based diets] on some of the most deleterious cardiovascular and metabolic disorders usually associated with renal failure,” such as hypertension and diabetes, “provide rationale for recommending a predominance of proteins from a vegetable source” for patients with failing kidneys.

Yet, diet is still underutilized, in part because some people find changing their diet is difficult. Yet, we know foods rich in animal protein lead to metabolic acidosis. Our diets “are largely acid-producing because they are deficient in fruits and vegetables and contain large amounts of animal products.” So, what did doctors do? They gave people baking soda. Instead of treating the cause––the dietary acid load from too many animal products and too few fruits and vegetables––they treated the consequence by saying, “Oh, too much acid? We’ll just give you some base: sodium bicarbonate.” And it works. Neutralization of dietary acid with sodium bicarbonate decreases kidney injury and slows kidney function decline, but sodium bicarbonate (baking soda) has sodium, so doctors may be just adding another problem.

If patients are not going to cut back on animal products, they should at least be eating more fruits and vegetables. They tried that, and it worked, too, and did so without leading to too much potassium in the blood. In fact, it may even work better because fruits and vegetables have the additional advantage of helping to lower blood pressure. The study that examined this is important because it illustrated a simple and safe way to treat metabolic acidosis: with fruits and vegetables. So, the key to halting the progression of chronic kidney disease might be in the produce market or the farmer’s market, not in the pharmacy.

This is the last in an extended six-part series on the latest science on diet and kidney health. Check out the rest of the series:

You may also be interested in my videos How Not to Die from Kidney Disease and How to Prevent Kidney Stones with Diet.

You have to have functioning kidneys to keep you in balance. The problem for most people is not getting enough potassium, which I discuss in my video 98% of American Diets Potassium Deficient, but too much phosphorus in the blood can also be a problem. Thus, phosphate additives are something we should try to avoid. For more on this, see:

In health,
Michael Greger, M.D.

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live, year-in-review presentations:

Which Vegetables Have the Most Nitrates?

What is the optimal timing and dose of nitrate-containing vegetables? In terms of timing for improving athletic performance, since every person is different, two to three hours before a competition is about as specific as we can get.

What about the best dose? How much borscht do we have to have for breakfast? To date, most studies have used a narrow range of doses so it’s not clear if it’s a matter of more is better or if there’s a ceiling, or threshold amount. A group of researchers decided to find out. They set up folks on an exercise bike and had them cycle furiously until they dropped. The subjects made it about eight minutes after drinking a placebo. After one shot of beetroot juice, which is about a quarter of a cup, they may or may not have gained a few seconds. However, drinking a half-cup gave them about a full extra minute. Drinking even more didn’t seem to offer any additional benefit.

That half-cup or so of beet juice corresponds to 8 “units” of nitrate. So, 4 units didn’t significantly work, and 16 did no better than 8. Thus, 8 units appear to be the sweet spot for improving athletic performance. What about for lowering blood pressure? Again, we see the same thing. Blood pressure may have been helped a little by 4 units, but 8 worked better and about equally well as 16. A 10-point drop in blood pressure, which may not sound like a lot, but that may translate into dropping heart attack risk by 25% and stroke risk by 35%.

But, beet juice is perishable and hard to find. What about V8 juice, which has both beet and spinach juice? It must not have much, though, because you’d have to drink 19 quarts a day to hit the target. That why I have a cooking video on making my own!

Straight beet juice is nitrate-packed, but it’s a processed food. How many actual beets or green leafy vegetables would one have to eat to reach the target of eight units? Well, the British Heart Foundation did the work for you and produced a useful chart that you can see in my “Veg-Table” Dietary Nitrate Scoring Method video at the 2:10 minute mark. They took into account both nitrate concentration and serving size for a range of foods, and arranged all of the foods into three groups: a high nitrate group that’s worth two nitrate units per serving, a medium group that’s worth about a half unit per serving, and a low nitrate group that’s worth one-tenth of a unit per serving. The serving sizes they analyzed are pretty small, though, less than three ounces. (Remember, we’re trying to get up to eight units a day.) So, a typical 15-ounce can of beets would nail the daily eight-unit target, as would a really big salad of greens, both of which are in the high nitrate group. Most people only get about a unit a day, and even vegetarians need to double their vegetable intake, and those eating organic may have to eat even more.

Organic produce may have more vitamin C, iron, magnesium, and phosphorus, but it tends to have fewer nitrates since synthetic nitrogen fertilizers are banned by law from organic agriculture. Eating 15% more organic veggies to get the same nitrate intake is easy, but, for beets, the spread can be larger. On the other hand, organic beets may have more of certain phytonutrients, like the red pigment for which beets are known, which may explain why the organic beet extracts had significantly higher anti-cancer effects in vitro compared to conventional beets.

For more information on why one would want to boost their nitrate consumption, check out these videos: Whole Beets vs. Juice for Improving Athletic Performance, Oxygenating Blood with Nitrate-Rich Vegetables, and Slowing Our Metabolism with Nitrate-Rich Vegetables.

If you really want to take a really deep dive into the background of this fascinating area, see my original 16-part series:

  1. Doping with Beet Juice
  2. Priming the Proton Pump
  3. Don’t Use Antiseptic Mouthwash
  4. Out of the Lab & Onto the Track
  5. Asparagus Pee
  6. Pretty in Pee-nk
  7. Vegetables Rate by Nitrate
  8. Is Bacon Good or Is Spinach Bad?
  9. When Nitrites Go Bad
  10. Hearts Shouldn’t Skip a Beet
  11. Bacon and Botulism
  12. Are Nitrates Pollutants or Nutrients?
  13. Prevention Is Better Than Cured Meat
  14. Carcinogens in the Smell of Frying Bacon
  15. Vitamin C-Enriched Bacon
  16. So Should We Drink Beet Juice or Not?

In health,

Michael Greger, M.D.

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live, year-in-review presentations: